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- Review Host-Pathogen Interactions in Urinary Tract Infections
- Young Hwii Ko, Jae Young Choi, Phil Hyun Song
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Urogenital Tract Infection 2019;14(3):71-79.
DOI: https://doi.org/10.14777/uti.2019.14.3.71
Published online: December 31, 2019
Department of Urology, College of Medicine, Yeungnam University, Daegu, Korea
Received: 18 September 2019 • Revised: 20 October 2019 • Accepted: 18 November 2019
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Abstract
Urinary tract infections (UTIs) are classified by the host condition. Uncomplicated infections are caused most commonly by uropathogenic Escherichia coli (UPEC) and affect otherwise healthy people, whereas complicated infections are commonly caused by species, such as Proteus mirabilis, and affect patients with underlying difficulties, such as a urinary tract abnormality or catheterization. The outcome of infection caused by these bacteria is dictated by the immune response to the UTI and the host factors that influence the susceptibility to disease. This review focuses on the host pathogen interactions in UTI, including an identification of additional virulence factors and therapeutic or prophylactic targets, particularly by UPEC and P. mirabilis.
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