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Role of Presepsin as a Predictive Factor for Sepsis in Patients With Urinary Tract Infection Associated With Ureteral Calculi: A Retrospective Cohort Study
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Jong Gyun Ha, Hee Chang Jung, Yeong Uk Kim
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Urogenit Tract Infect 2026;21(2):89-95. Published online August 31, 2026
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DOI: https://doi.org/10.14777/uti.2652014.007
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 Abstract
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- Purpose
Recently, multiple studies have reported presepsin as a useful inflammatory biomarker for early sepsis diagnosis in patients with urinary tract infections (UTIs). Nonetheless, few studies have evaluated the efficacy of presepsin in urosepsis associated with ureteral calculi. We retrospectively investigated the efficacy of presepsin for early urosepsis diagnosis associated with ureteral calculi.
Materials and Methods: Between May 2021 and July 2023, 64 patients with UTI associated with ureteral calculi were included. Sepsis was defined as a Sequential Organ Failure Assessment (SOFA) score increase of ≥2 points. Patients were divided into 2 groups, with (n=38) and without (n=26) sepsis, and we assessed clinical characteristics (age, sex, and past medical history), laboratory data, and stone characteristics. Additionally, we evaluated predictive factors for urosepsis associated with ureteral calculi and compared these factors with inflammatory biomarkers.
Results
The proportion of females in the sepsis and nonsepsis groups was 89.5% (n=34) and 61.5% (n=16), respectively. In univariable analysis, low albumin level, low platelet count, and presepsin and procalcitonin (PCT) levels correlated with sepsis (p<0.05). In univariable logistic regression analysis, quick SOFA (odds ratio [OR], 2.071; p=0.033), C-reactive protein (CRP; OR, 1.08; p=0.01), PCT (OR, 1.025; p=0.008), and presepsin (OR, 1.354; p=0.001) were significantly associated with sepsis. In multivariate logistic regression analysis, presepsin (OR, 1.321; p=0.003) was significantly associated with sepsis. In receiver operating characteristic curve analysis of inflammatory markers, the areas under the curve for CRP, PCT, and presepsin were 0.704, 0.777, and 0.814, respectively.
Conclusions
Elevated presepsin levels may help predict sepsis occurrence in patients with UTI associated with ureteral calculi, thereby supporting timely and appropriate intervention.
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Intraurethral Instillation of 5-fluorouracil with Suprapubic Cystostomy for Intraurethral Condyloma Acuminatum
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Jong Gyun Ha, Young Hwii Ko, Yeong Uk Kim
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Urogenit Tract Infect 2023;18(1):32-34. Published online April 30, 2023
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DOI: https://doi.org/10.14777/uti.2023.18.1.32
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Abstract
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- Condyloma acuminatum is a common sexually transmitted disease caused by the human papillomavirus and with a high recurrence rate in the urethra. We report the intraurethral instillation of 5-fluorouracil cream for intraurethral condyloma acuminatum with suprapubic cystostomy after transurethral surgery. A 64-year-old man had gross hematuria for several days. At cystourethroscopy, multiple papillary mass lesions were identified on the entire urethra. Transurethral resection of the urethral masses confirmed the diagnosis of condyloma acuminatum. However, recurrent multiple warts were identified on the whole urethra. After re-surgery, intraurethral instillation of 5-fluorouracil cream with suprapubic cystostomy was achieved to prevent a recurrence. After one year of 5-fluorouracil instillation, there was no recurrence of intraurethral condyloma acuminatum.
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