Urogenital Tract Infection

Table. 3.

Pre- and post-antibiotics treatment semen parameters in subfertile males with bacteriospermiaa)

  U. parvum U. urealyticum M. genitalium



Pre-Tx (n=22) Post-Tx (n=17)d) p-valuee) Pre-T x (n=24) Post-Tx (n=21) p-value Pre-Tx (n=11) Post-Tx (n=10) p-value
Semen parametersb)
Volume (ml) 2.1±1.5 2.8±0.8 0.144 2.2±1.9 2.7±2.0 0.157 2.3±1.3 2.9±1.6 0.209
Sperm concentration (106/ml) 45.0±12.9 48.2±13.4 0.528 44.8±15.5 45.0±14.2 0.782 43.2±17.0 45.0±9.7 0.611
Total motility (%) 17.8±3.1 41.4±5.7 <0.001 17.5±6.9 47.0±10.1 <0.001 18.0±7.7 42.1±5.4 <0.001
Progressive motility (%) 7.9±4.3 31.7±5.9 <0.001 7.3±8.2 37.1±9.6 <0.001 9.2±5.6 32.9±6.2 <0.001
Leukocytospermia (106/ml) 3.0±1.4 0.4±0.4 <0.001 3.1±1.6 0.3±0.1 <0.001 3.0±1.2 0.5±0.2 <0.001
DNA fragmentation (%) 44.6±10.5 30.2±11.5 <0.001 45.7±8.6 31.4±5.3 <0.001 43.1±11.9 30.3±7.8 <0.001
Normal morphology (%) 1.1±0.5 1.1±0.9 0.560 1.1±1.3 1.2±1.1 0.617 1.5±0.8 1.5±1.0 0.770
Vitality (%) 47.9±6.5 50.4±7.3 0.284 45.2±8.4 47.5±10.3 0.589 46.5±6.1 49.0±11.4 0.331
Recurrence of bacterial infectionc) - 5 (31.8)   - 3 (12.5)   - 1 (9.1)  
G. vaginalis A. vaginae S. agalactiae
Pre-Tx (n=8) Post-Tx (n=8) p-value Pre-Tx (n=4) Post-Tx (n=3) p-value Pre-Tx (n=16) Post-Tx (n=16) p-value
Semen parametersb)
Volume (ml) 3.1±1.2 3.7±1.5 0.151 3.4±2.8 3.5±2.0 0.682 3.2±0.9 3.1±1.5 0.701
Sperm concentration (106/ml) 42.7±18.4 45.7±.10.5 0.553 49.9±17.2 52.9±10.3 0.604 39.1±10.9 42.1±10.6 0.728
Total motility (%) 22.1.±7.3 24.1±6.2 0.722 23.6±3.5 23.0±5.1 0.916 20.7±8.2 24.0±5.1 0.611
Progressive motility (%) 12.2±3.5 14.9±6.1 0.619 14.0±2.8 14.1±4.7 0.738 10.5±5.4 14.8±6.0 0.392
Leukocytospermia (106/ml) 2.2±1.7 0.2±0.1 0.001 2.5±1.3 0.6±0.2 0.001 3.5±1.5 0.3±0.1 <0.001
DNA fragmentation (%) 41.9±14.2 39.5±12.8 0.214 41.0±14.3 41.8±9.9 0.312 45.0±9.7 43.9±8.6 0.151
Normal morphology (%) 1.7±0.6 2.9±0.7 0.011 1.6±0.8 1.6±1.1 0.701 1.0±0.7 3.2±0.9 0.045
Vitality (%) 52.3±5.0 53.1±4.4 0.834 53.0±1.8 54.7±3.1 0.613 44.5±6.4 46.0±8.2 0.535
Recurrence of bacterial infectionc) - 0 (0.0)   - 1 (25.0)   - 0 (0.0)  
  P. bivia E. faecalis M. curtisii
Pre-Tx (n=74) Post-Tx (n=74) p-value Pre-Tx (n=17) Post-Tx (n=17) p-value Pre-Tx (n=4) Post-Tx (n=3) p-value
Semen parametersb)
Volume (ml) 2.5±1.4 3.0±1.2 0.173 2.1±0.8 2.5±1.4 0.383 3.1±0.7 3.5±0.5 0.415
Sperm concentration (106/ml) 31.6±19.1 47.9±19.1 0.039 29.8±11.3 51.0±13.2 0.022 44.0±12.5 43.1±13.0 0.901
Total motility (%) 16.4±11.7 49.3±12.6 <0.001 23.7±4.4 40.8±13.4 <0.001 22.4±6.1 25.1±7.2 0.730
Progressive motility (%) 7.8±4.7 39.7±11.8 <0.001 13.6±3.9 31.3±5.1 <0.001 11.1±2.7 16.3±4.0 0.526
Leukocytospermia (106/ml) 3.6±1.1 0.3±0.2 <0.001 3.3±1.4 0.4±0.3 <0.001 2.6±1.5 0.3±0.3 <0.001
DNA fragmentation (%) 45.1±11.1 33.6±9.5 <0.001 43.0±12.4 41.7±18.0 0.001 41.6±7.8 41.4±10.8 0.796
Normal morphology (%) 1.8±0.5 2.0±1.3 0.127 1.5±1.1 1.6±0.9 0.636 1.6±0.4 1.6±0.9 0.659
Vitality (%) 48.7±7.2 58.0±4.1 0.029 49.9±5.3 59.2±8.4 0.018 44.9±5.7 47.4±9.2 0.627
Recurrence of bacterial infectionc) - 0 (0.0) - 0 (0.0) - 1 (25.0)
Semen parameters  
Volume (ml) 2.1±0.9 3.0±1.7 0.140 2.9±1.7 3.1±1.4 0.507
Sperm concentration (106/ml) 30.9±16.6 32.1±12.6 0.609 43.3±17.4 54.1±15.3 0.047
Total motility (%) 22.1±8.6 41.0±10.8 <0.001 20.4±10.0 35.8±8.2 0.031
Progressive motility (%) 13.3±4.8 32.3±6.1 <0.001 11.1±5.3 26.5±6.5 0.027
Leukocytospermia (106/ml) 4.0±0.9 0.5±0.2 <0.001 2.8±1.9 0.4±0.2 0.014
DNA fragmentation (%) 46.4±8.1 42.1±10.1 0.129 43.2±13.8 37.6±10.4 0.001
Normal morphology (%) 1.0±0.7 1.2±0.5 0.517 1.5±1.2 1.8±1.0 0.464
Vitality (%) 44.4±5.9 46.3±11.7 0.805 51.7±6.1  51.1±7.8 0.655 
Recurrence of bacterial infectionc) - 0 (0.0)     11 (6.1)   

Values are presented as mean±standard deviation or number (%).

U. parvum: Ureaplasma parvum, U. urealyticum: Ureaplasma urealyticum, M. genitalium: Mycoplasma genitalium, G. vaginalis: Gardnerella vaginalis, Tx: treatment, DNA: deoxyribonucleic acid, A. vaginae: Atopobium vaginae, GBS: Streptococcus agalactiae, P. bivia: Prevotella bivia, E. faecalis: Enterococcus faecalis, M. curtisii: Mobiluncus curtisii, C. trachomatis: Chlamydia trachomatis, –: not available.

a)Genitourianry tract bacterial presence indicates bacterial infection confirmed in urine or semen samples. b)Semen parameters are presented in mean±standard deviations. c)Recurrence rate was evaluated at 3 months after the initial antibiotics treatment. d)Post-antibiotics treatment semen analysis was performed on the patient who had no bacterial reinfection at 3 months after the initial antibiotics treatment. e)p-vlaues <0.05 are printed in bold characters.

Urogenit Tract Infect 2023;18:82-92 https://doi.org/10.14777/uti.2023.18.3.82
© 2023 Urogenit Tract Infect