Urogenital Tract Infection

Table. 1.

Studies on healthy human urine microbiome

Study population Main bacterial taxa Sample collection Technique used Ref
Healthy men aged ∼18 yr (n=9) Lactobacillus, Corynebacterium, Escherichia, and Streptococcus FC urine 16S rRNA GS [11]
Healthy men (n=22) age≥18 yr, median 28 yr Lactobacillus, Sneathia, Veillonella, Corynebacterium, Prevotella, Streptococcus, Ureaplasma, Mycoplasma, Anaerococcus, Atopobium, Aerococcus, Staphylococcus, Gemella, Enterococcus, and Finegoldia FC urine 16S rRNA GS [15]
Healthy females aged 27–67 yr (n=8) Lactobacillus, Prevotella, Gardnerella, Peptoniphilus, Dialister, Finegoldia, Anaerococcus, Allisonella, Streptococcus, and Staphylococcus CC MSU 16S rRNA GS [12]
Healthy males aged 24–50 yr (n=11)
Healthy females aged 22–51 yr (n=15)		 Lactobacillus, Klebsiella, Corynebacterium, Staphylococcus, Streptococcus, Aerococcus, Gardnerella, Prevotella, Escherichia, and Enterococcus MSU 16S rRNA GS [16]
Healthy males aged 14–17 yr (n=18) Corynebacterium, Lactobacillus, Staphylococcus, Gardnerella, Streptococcus, Anaerococcus, Veillonella, Prevotella, and Escherichia FC urine 16S rRNA GS [18]
Healthy women (n=12) age NA Lactobacillus, Actinobaculum, Aerococcus, Anaerococcus, Atopobium, Burkholderia, Corynebacterium, Gardnerella, Prevotella, Ralstonia, Sneathia, Staphylococcus, Streptococcus, and Veillonella CC MSU, SPA, and TUC 16S rRNA GS [13]
Healthy men aged 39–86 yr (n=6)
Healthy woman aged 26–90 yr (n=10)		 Male and female samples: Firmicutes; female samples: Actinobacteria, Bacteroidetes CC MSU 16S rRNA GS [17]
Healthy women (n=24) age NA Lactobacillus, Corynebacterium, Streptococcus, Actinomyces, Staphylococcus, Aerococcus, Gardnerella, Bifidobacterium, and Actinobaculum TUC 16S rRNA GS and/or EUCT [6]
Healthy women aged 35–65 yr (n=58) Lactobacillus, Gardnerella, Corynebacterium, Enterobacteriaceae, Anaerococcus, Bifidobacterium, Streptococcus, Staphylococcus, Sneathia, Peptoniphilus, Atopobium, Rhodanobacter, Trueperella, Alloscardovia, and Veillonella TUC 16S rRNA GS and/or EQUC [19]
Healthy women aged 35–65 yr (n=60) Lactobacillus, Gardnerella, Staphylococcus, Streptococcus, Enterococcus, Bifidobacterium, Atopobium, and Enterobacteriaceae TUC 16S rRNA GS and/or EQUC [20]
Healthy women (n=10) Anoxybacillus, Lactobacillus, Prevotella, Gardnerella, Arthrobacter, Escherichia, and Shigella TUC 16S rRNA GS [14]

FC: first catch, CC: clean catch, MSU: mid stream urine, SPA: suprapubic aspirate, TUC: transurethral catheter, GS: gene sequencing, EUCT: enhanced urine culture technique, EQUC: expanded quantitative urine culture.
Urogenit Tract Infect 2023;18:1-7 https://doi.org/10.14777/uti.2023.18.1.1
© 2023 Urogenit Tract Infect